Dera Ismail Khan often abbreviated to D. I. Khan, is a city and capital of Dera Ismail Khan District, located in Khyber Pakhtunkhwa Province, Pakistan. It is the 37th largest city of Pakistan and the fifth largest in the province of Khyber Pakhtunkhwa by population. Dera Ismail Khan is situated on the west bank of the Indus River, about 300 kilometers (190 mi) south of the provincial capital Peshawar, and 230 kilometers (140 mi) northwest of Multan, Punjab.